A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. They are characterized by the systems properties of gene networks and their interrelations, instead of individual genes, whose malfunctioning manifests in pathological phenotypes, thus making the analysis of the resulting large data sets particularly challenging. This is why novel approaches are needed to tackle this problem efficiently on a systems level. Written by computational biologists and biostatisticians, this book is an invaluable resource for a large number of researchers working on basic but also applied aspects of biomedical data analysis emphasizing the pathway level.

This book is the first to focus on the application of mathematical networks for analyzing microarray data. This method goes well beyond the standard clustering methods traditionally used.
From the contents:
* Understanding and Preprocessing Microarray Data
* Clustering of Microarray Data
* Reconstruction of the Yeast Cell Cycle by Partial Correlations of Higher Order
* Bilayer Verification Algorithm
* Probabilistic Boolean Networks as Models for Gene Regulation
* Estimating Transcriptional Regulatory Networks by a Bayesian Network
* Analysis of Therapeutic Compound Effects
* Statistical Methods for Inference of Genetic Networks and Regulatory Modules
* Identification of Genetic Networks by Structural Equations
* Predicting Functional Modules Using Microarray and Protein Interaction Data
* Integrating Results from Literature Mining and Microarray Experiments to Infer Gene Networks
The book is for both, scientists using the technique as well as those developing new analysis techniques.